We have made changes in the way email is handled. By employing the SMTP “reply-to” function, system invite messages sent to candidates and references now include a “reply-to” address for the investigator sending the invitation. While the message is still from “firstname.lastname@example.org” for optimal deliverability, any reply to the message goes to the sending investigator. In the past, if the recipient replied to these messages, the reply went to email@example.com. Similarly, any responses from the receiving email server such as bounce notifications were also sent to firstname.lastname@example.org. Now, by employing the reply-to function in the email, these responses and replies are sent to the investigator sending the invitation. The main benefit is that the investigator will receive bounce notifications and be made aware when an email has not been delivered. Additionally, recipients regularly reply to these messages even though the first sentence of the message was “DO NOT REPLY TO THIS MESSAGE”. We have removed that language now since the messages can be replied to, so investigators can expect to receive occasional responses from the recipients.